Replacing the Spark Plugs?

Not unless the service data says to. Most plugs that require a coating will be plated with the coating from the factory. Anything added to the threads can cause the heat transfer between the plug and head to be wrong and then the plug runs hotter and can cause issues. In your case service info says gap should be between.039 and.051 so.042 or so as a middle ground. Then a dry install, torque to 18ft lb. That is another area where any lubricant can cause issues, because it reduces friction you could easily over torque or worse strip the threads in the head.

Hello, below is a guide to replacing the spark plugs, I dont usually put any anti seize on the plug threads, unless there is rust present when removing the old ones, the reason I dont personally is because the spark plugs are designed so they dont need it. But if you are concerned about it, a very small amount wont damage anything, but dont put it on all the threads, just a very small amount on the lower threads and it will spread while screwing them into the cylinder head. Also below is the type of spark plugs for your vehicle as well as the torque specs for them. Some plugs come with crush washers, so dont over tighten them once the washer is fully seated.
Are you getting any cylinder misfiring or codes with the check engine light on?

https://www.2carpros.com/articles/how-to-change-spark-plugs