Misfire on rough running engine. No CEL

My escape has a misfire 5 cylinder
I was told to try tuneup which was done
25,000 ago. What else should I try
I get the parts for my mechanic and he charges me for
Labor. What should I get for tuneup other than wires
and plugs

Thanks
minkmanse

Already did that twice and within 100 miles ran crappy
again and light back on either blinking or stays on
Going to try tuneup next with new wires and plugs
What other things would I change for a good tuneup
I have a friends mechanic doing but he doesn't speak
good English and hoping you can list what parts needed for
tuneup to maybe help my issue

What do I do when there's a cylinder 4 misfire on a 2001 Ford Escape V6?

Thank you

How I check if the car time is off fuel is present in cylinder 4 and 6 thank you for quick fix

Car misfire in cylinder 4 and 6 check engine light is on and blink and strong fuel smells went you drive

Car misfire in cylinder 4 and 6 check engine light is on and blink and strong fuel smells went you drive I replace spark plugs ingition coils PVC valve

Cylinder 2 is misfiring intermittently. The only code that registers on the computer is cylinder 2 misfire. This has occurred off and on for the last two weeks. I have taken it to three different shops (including Ford and an electrical auto shop) over that time but still experience the same problem. Mechanics have replaced #2 coil, #3 coil, all 6 spark plugs, the plug boots, and six o ring gaskets.

One mechanic said if it is the fuel injector the computer would throw a different code, but I an beginning to fear this.

What else could be wrong? The wiring? Any suggestions of who I should take it to next?