Runs rough when engine is warm

No the p102 code is gone but p300 now there because of multp- misfires

I unpluged the old one before and still ran bad, that.S why I replaced it

First off it's 5.3, When I was coming back from up north from hunting it ran fine over 250mi. No issue's. Then it started to run bad after stopping at stop light. You know what else I already did, the throttle body was replaced last year. So now i.M leaning towards a vacume leak or pcm? Thanks for your help on this issue. (:

So here I am in cold garage, sprayed carb cleaner all around intake no change at all. Re-scan again get code for map sensor so replace it same thing! Po106, while it's sorta running pul coil connectors and #1-2-3-4-5 are dead no change in running so swap coil pack from a good hole and still dead! So are we looking at pcm or other area?

Checked the voltage on coils and there hot w/key on

JDL- With christmas upon us here the truck is going to have wait until wend. Then i'll have a multimeter to check it out, ? Could the ground be out on them coil pack's and could I use a jumper to ground one to see if would fire that cyl? Thanks for all your help today as my head is pounding so off for holiday cheer! Merry-Christmas

Crankshaft position sensor

So got better scanner now #1 & #3 have mise fire, shows lean or - fuel trim on #1 and #2 bank disconnect bank 1 sensor 2 with no change at all, check spark on # which is good and also check for pulse on injectors which are good, seems like it's dumping fuel into them two clyinders on idle but when I pick up rpm's still runs bad but not as badwith lot of raw gas coming out. I'M VERY CLOSE CLOSE TO TAKING IT TO CHEVY GARAGE TO FIND OUT WHAT THE HELL IS GOING ON!

So JDL is there any way to test a pcm? Any thing short of taken to a dealer, some one suggested the crank sensor but i'm thinking it would not run at all because if it does not pick up #1 cyl it would not cycle the firing for the other cyl? I sure don't wont to keep trowing parts at it to see if thats the problem thanks again real stumper!

So today I spent some time with it, did compression test and have 180psi in #1 and #3 replaced the fuel injectors on bank 1 no change. Put a vacume gauge to pvc line has vacume but gauge is bounching around. Check with scanner and tp sensor shows nothing or should I say no change with throttle, this was replaced 2yrs. Ago, I don't know if there was an issue with the intake or the gaskets on the 5.3 was thinking egr valve don't think it has one or I could not find it as check for it. There was a bullitin for misfire cause by bad ground but where it say's the ground is not there ie right front of head.