The vehicle makes a very load noise when accelerating

There is a very loud, low toned noise coming from the front of the vehicle either in right in front of the steering wheel or around the front left wheel. The noise subsides at some speeds and is actually quietest at 80 mph on the interstate. I checked the tires and under the front end but didn't see an obvious signs that something was wrong. My son just drove 600 miles with this condition. The transmission seems fine and everything else seems to work fine except for this loud noise.