Car bucks really hard/jerks/hesitates?

While I'm driving my car, randomly the car will do a major jerk or hesitation and lose a lot of power in the moment. It does not do it often, maybe every couple hundred miles or every other day (I'm a gig driver so I put a lot of miles on my car a day) but I am not too sure where to start to try and fix this problem. It only happens every so often, but when the car does buck/jerk, it's a pretty violent jerk that it does. This has been going on for a few months now. I'm leading towards a misfire or a vacuum leak, I have already tried to use fuel injector cleaner in my gas tank, and it has not gotten better, I replaced my spark plugs, which did nothing. I just really wish I knew where an easy start would be because cleaning the fuel injectors and filter is a lot to do and also checking the pump to make sure it's working still, then checking the PCV valve and other valves is another thing, or the vacuum hoses or mass air flow, I'm just not sure if someone may know with this model if it's something more specific than just a broad answer of anything that causes a car to jerk or hesitate. I'm not sure if it's a mixture problem which would be air/ fuel/ oil problems and stuff, I'm just not a mechanic but I've done a lot for my car just by looking up on YouTube what to do, I'm just trying to get a general idea from someone that may of worked on this model and car with the same issue and maybe how they fixed it!