Acceleration problems and jerks at highway speeds

For the code p0101. Did this code return after replacing the mass air flow. This sensor is one of the main sensor for the vehicle's computer to determine proper fuel injection. If all sensors are not working to design it could cause driveability issues such as acceleration.

Check the transmission fluid level for the jerking issue. If you can check to see if there is any codes stored for the transmission computer. If it isn't misfires your feeling it sounds more like the transmission specifically the torque converter clutch.

It doesn't seem like a vacuum issue because vacuum leaks are more prevailent at idle when vacuum is at its highest.

The other code P0410 is for the air injection pump not working. Its usually the pump itself or an issue with the wiring to the pump including the relay. I don't think this would cause any of the issues above it's just to reduce emissions on engine start up.

The other code p0410 will still cause the check engine light to be on. You'll need to see if it is still there You'll need to clear those codes to be sure and then the vehicle will need to be driven for the cars computer to do it's self test (usually takes several days of normal driving for all the self test to complete).

When checking automatic transmission fluid in Cadillacs the transmission fluid must be warmed up from normal everyday driving with the engine running. The car must also be parked on a flat level surface to reflect the actual fluid level. With the engine off checking the transmission fluid level will be higher than actual.

Usually if a fault in the transmission is detected there would be a check engine light for that but not always. The reason I brought up the torque converter clutch is that is really the only part of the transmission that is switching (on off) at free way speed cruising. And not really involving shifting.

There is a lot parts that can cause misfires so I'll go more into that later because Mass air flow sensor and the transmission fluid level. If you'll like me to go more into misfires I can but I wanted to start with the basic and easier to check before jumping into something else.

If it comes back it could be wiring but usually it is just the sensor itself.

To add trans fluid you use a funnel and pour directly into the tube the dipstick is in. You'll need to wait a minute or two for the fluid to drain out of the this tube because is will get all over the dipstick when checking fluid level making it difficult to read the correct fluid level. I pour fluid in while it is running since you need to check fluid level with the engine running.

I'll list a few things that could cause like a hesitation at full throttle.

Low transmission fluid level ( enough fluid is required to propel the vehicle)
Fuel restriction or low fuel pressure could cause this but is usually more noticeable when accelerating (all acceleration) not just full throttle.
You could have some exhaust system restriction
The transmission fluid level seems the most logical at this time.
Because this only an issue when accelerating at full throttle I don't really see a significant issue not to drive the car.