Hello, I'm Danny.
If you are going to unplug the radio I would do so with the radio turned off. As far as the only problem I foresee is that some car makers with their factory(stock) radios will sometimes require a radio code when the factory radio is plugged back in or reinstalled to get to work again. Hope this helps and thanks for using 2CarPros.
Thursday, April 30th, 2020 AT 7:04 PM