2005 Honda CRV Power Door Locks

The vehicle has power door locks and a couple of weeks ago, when hitting the lock button it no longer would beep the horn after hitting the button twice to tell us the doors would lock. We then realized that the front driver's side door was not locking but all other doors were locking. The past few days, now the remote will not lock any of the doors so we must manually lock and unlock. I have check the fuse box and they all appear to be fine. Any suggestions.