2000 Honda Accord what should I look for

Best bet is to make an appointment with your regular mechanic and have him give it a once over. If your state has an inspection do it separatly from the dealer.

Check to find what maintenance records there are on it. You can use carfax, but don't put much stock ito it.

Tesrt drive it at various speeds and braking for anything abnormal, check fluid conditions, battery age. Use all dash accessories for operation including a/c.