2005 Ford F-150

I have a 2005 ford F-150 with 97k I have used fuel injection cleaner in the past without issue. I put gas in my truck today and a bottle of fuel injection cleaner drove about a 100 miles with no issue. At the end of the day I started my truck to head home and the engine light was on and the idle was rough when I started to drive the engine acted as if it is missing or not running on all cylinders I put more gas in the tank and it slightly improved but still missing and engine light is on and flashes when driving I was wondering if anybody had any suggestion as to why this may be missing i.E. Injectors, plugs, wires, coil pack etc.