1992 Chevy Cheyenne Engine will not crank

I have a 1992 Chevy Cheyenne Pickup, 2500 Series
with 47,000 original miles. The engine lost power while I was driving down the interstate and lost power. The ignition turns over but will not fire. The check engine light, check gauges and battery light icon comes on.
This happened twice over a two month period but the engined cranked when allowing the vehicle to sit for a brief period. I had the fuel filter changed and also changed all plugs, rotor and wires.
Still the engine turns over but will not fire. Any suggestions.

Steve