Car running rough intermittently?

I was driving my car back from work when it ran rough a few times. When I got back home I put it on the cofe reader I have and the codes p0221 and p2135 came up. The check engine light came on while in the code position but not while I was driving. It just gave me codes nothing as to what needed fixed. I was wondering if using a fuel injector cleaner would help with this or spark plugs or would it be something with the throttle body?