300,171,174 code

I keep getting a 171-174 code, This is a lean condition both banks. I also get a 300 code. This is random miss-fire. It bucks at part throttle when its cold until the temp gauge reads 195 when the themostat opens. This is in a 2000 S-10 4.3 V6 with 190,000 miles. Do the fuel injectors need to be cleaned? Has anybody had this same problem. Thanks, Roger