2000 Toyota Camry Code: PO401 & PO446

2000 Toyota Camry 4 cyl Automatic 81000 miles
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Hello,

I have a 2000 Toyota Camery LE, 4 cyl. I recently got trouble codes "PO401" & "PO446". My question is what exactly does this mean, and how can i repair it? Tell me approximately the cost of repair this problem.

Thanks,
Jatin