Number one cylinder misfire code P0301

Sometimes the check engine light will come on causing to throw off the p0301 code. The check engine light will eventually turn off then about two or three weeks later it will come back on. Now it is staying on and runs rough when the light turns off. It runs fine but now that the light is staying on and will not shut off. It is running rough but it is not backfiring while driving, it just runs rough especially at a idle. Also, you can hear a small tick but not bad for it to be a damaged engine because it does not over heat at all.