1990 Toyota Pickup dies after a few miles

My 4x4 1990 toyota pickup runs good for about 2 miles then the engine light comes on and it loses all speed. It will usually stay running but you can only go 5 or 10 mph, or it will stall right out at a stoplight. If I let it sit for a while it runs good again for about the next 2 miles. I thought this might have been a coil or fuel pump problem, so they have both been replaced and no change. It has the 22RE 2.4L engine. The engine has had a knock for over a year, but it has always run strong. It has an automatic transmission and this is the second engine. I put this engine in about a year and a half ago. When I jump a wire for the code, it reads 52, for knock sensor. The engine knocks so does that mean the knock sensor is working and its time for a new truck or is this a fixable problem? Thank you so much for any help, I'm stuck in Buffalo, New York without a 4x4. We just got a foot of snow yesterday!