2000 Ford Taurus engine misses when engine light comes on

Engine light came on. I replaced o2 sensor twice. The engine light came back on two days later. The engine has started to miss and there is no exceloration, and the car will stop. the engine remains running. I remove the negative wire from the battery and recycle the computer. This only works for a short period of time. The car will run down hill , but still misses. Could the car have bad plugs? Thanks, Earl