Computer problem
1997 Ford Ranger 6 cyl Two Wheel Drive Automatic 150000 miles
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P1443 Manufacture control Aux. emission controls.
P0171 System too Lean Bank 1
P0302 Cylinder 2 misfire detected
P0305 Cylinder 5 misfire detected
P0402 EGR flow excessive

This are the codes that came up on the scanner.
Plus now it is also in the red on the water guage.

Would a tune up fix these problems and where do I begin?

I have not seen any leakage of Radiator fluid as of yet but the reservoir tank was empty,so I added water to get me home and the meter stead inside the high safe zone as long as I did not stop for a period of time.

Noticed any white smoke from tailpipe?
Does it run rough on start up after sitting all night?
Check oil look normal?

no sign of smoke white or black/gray
yes it runs a bit rough all the time
Oil looks great all fluid up to par.

overheating problem resolved I found a small leak on the lower hose. It has been replaced and the fluids as well.

I got to resolve the code problems any further input.
thanks for helping.

First code I would look at is the EGR it can cause lean and missfire. Check to see if vaccum is on it at idle there should not. If so check the EGR solenoid. If all good remove clean out see if the pental is seating.
Where codes erased? If not after EGR check erase and drive see what resets.